About Adenosylhomocysteinase
Adenosylhomocysteinase (AHCY) is a protein
from Homo sapiens identified by UniProt accession
P23526, 432 residues long.
MolForge cross-references it against 0 known binders and
159 disease associations.
Target properties
| Protein name | Adenosylhomocysteinase |
|---|
| UniProt accession | P23526 |
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| Gene | AHCY |
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| Organism | Homo sapiens |
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| Length | 432 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
|---|
Approved drugs hitting this target (1)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (159)
Diseases linked to this target (Open Targets).
- hypermethioninemia with deficiency of S-adenosylhomocysteine hydrolase · score 0.77
- Psychomotor retardation due to S-adenosylhomocysteine hydrolase deficiency · score 0.76
- neurodegenerative disease · score 0.55
- genetic disorder · score 0.48
- lysosomal storage disease · score 0.42
- hydrops fetalis · score 0.37
- rhabdomyolysis · score 0.32
- appendicular lean mass · score 0.22
- multiple sclerosis · score 0.21
- Alzheimer disease · score 0.21
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P23526-F1 | alphafold | PREDICTED | 98.20 | — |
Amino-acid sequence (432 residues)
MSDKLPYKVA DIGLAAWGRK ALDIAENEMP GLMRMRERYS ASKPLKGARI AGCLHMTVET AVLIETLVTL GAEVQWSSCN IFSTQDHAAA AIAKAGIPVY AWKGETDEEY LWCIEQTLYF KDGPLNMILD DGGDLTNLIH TKYPQLLPGI RGISEETTTG VHNLYKMMAN GILKVPAINV NDSVTKSKFD NLYGCRESLI DGIKRATDVM IAGKVAVVAG YGDVGKGCAQ ALRGFGARVI ITEIDPINAL QAAMEGYEVT TMDEACQEGN IFVTTTGCID IILGRHFEQM KDDAIVCNIG HFDVEIDVKW LNENAVEKVN IKPQVDRYRL KNGRRIILLA EGRLVNLGCA MGHPSFVMSN SFTNQVMAQI ELWTHPDKYP VGVHFLPKKL DEAVAEAHLG KLNVKLTKLT EKQAQYLGMS CDGPFKPDHY RY
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