Histone H2B type 1-O (H2BC17)

About Histone H2B type 1-O

Histone H2B type 1-O (H2BC17) is a protein from Homo sapiens identified by UniProt accession P23527, 126 residues long. MolForge cross-references it against 0 known binders and 49 disease associations.

Target properties

Protein name	Histone H2B type 1-O
UniProt accession	P23527
Gene	H2BC17
Organism	Homo sapiens
Length	126 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (49)

Diseases linked to this target (Open Targets).

infectious disease · score 0.50
viral disease · score 0.50
breast carcinoma · score 0.39
cancer · score 0.37
melanoma · score 0.37
mean corpuscular volume · score 0.17
hemoglobin measurement · score 0.13
HbA1c measurement · score 0.06
apolipoprotein B measurement · score 0.06
low density lipoprotein cholesterol measurement · score 0.06

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P23527-F1	alphafold	PREDICTED	88.22	—

Amino-acid sequence (126 residues)

MPDPAKSAPA PKKGSKKAVT KAQKKDGKKR KRSRKESYSI YVYKVLKQVH PDTGISSKAM GIMNSFVNDI FERIAGEASR LAHYNKRSTI TSREIQTAVR LLLPGELAKH AVSEGTKAVT KYTSSK

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards