Cofilin-1 (CFL1)

About Cofilin-1

Cofilin-1 (CFL1) is a protein from Homo sapiens identified by UniProt accession P23528, 166 residues long. MolForge cross-references it against 0 known binders and 335 disease associations.

Target properties

Protein name	Cofilin-1
UniProt accession	P23528
Gene	CFL1
Organism	Homo sapiens
Length	166 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (335)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.51
breast adenocarcinoma · score 0.26
neutrophil count · score 0.22
cortical thickness · score 0.21
monocyte count · score 0.20
platelet crit · score 0.19
platelet count · score 0.18
head and neck squamous cell carcinoma · score 0.16
neuroblastoma · score 0.16
myeloid white cell count · score 0.13

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P23528-F1	alphafold	PREDICTED	87.56	—

Amino-acid sequence (166 residues)

MASGVAVSDG VIKVFNDMKV RKSSTPEEVK KRKKAVLFCL SEDKKNIILE EGKEILVGDV GQTVDDPYAT FVKMLPDKDC RYALYDATYE TKESKKEDLV FIFWAPESAP LKSKMIYASS KDAIKKKLTG IKHELQANCY EEVKDRCTLA EKLGGSAVIS LEGKPL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards