C-type natriuretic peptide (NPPC)

About C-type natriuretic peptide

C-type natriuretic peptide (NPPC) is a protein from Homo sapiens identified by UniProt accession P23582, 126 residues long. MolForge cross-references it against 0 known binders and 197 disease associations.

Target properties

Protein name	C-type natriuretic peptide
UniProt accession	P23582
Gene	NPPC
Organism	Homo sapiens
Length	126 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (197)

Diseases linked to this target (Open Targets).

body height · score 0.44
appendicular lean mass · score 0.39
lean body mass · score 0.33
fat body mass · score 0.33
forced expiratory volume · score 0.32
sitting height measurement · score 0.30
BMI-adjusted hip circumference · score 0.30
serum albumin measurement · score 0.30
balding measurement · score 0.26
neurodegenerative disease · score 0.25

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P23582-F1	alphafold	PREDICTED	62.35	—

Amino-acid sequence (126 residues)

MHLSQLLACA LLLTLLSLRP SEAKPGAPPK VPRTPPAEEL AEPQAAGGGQ KKGDKAPGGG GANLKGDRSR LLRDLRVDTK SRAAWARLLQ EHPNARKYKG ANKKGLSKGC FGLKLDRIGS MSGLGC

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards