About Eukaryotic translation initiation factor 4B
Eukaryotic translation initiation factor 4B (EIF4B) is a protein
from Homo sapiens identified by UniProt accession
P23588, 611 residues long.
MolForge cross-references it against 0 known binders and
100 disease associations.
Target properties
| Protein name | Eukaryotic translation initiation factor 4B |
|---|
| UniProt accession | P23588 |
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| Gene | EIF4B |
|---|
| Organism | Homo sapiens |
|---|
| Length | 611 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (100)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.36
- breast adenocarcinoma · score 0.28
- lung adenocarcinoma · score 0.25
- electrocardiography · score 0.23
- glioblastoma multiforme · score 0.19
- endometrial cancer · score 0.18
- body height · score 0.16
- IGF-1 measurement · score 0.14
- diffuse large B-cell lymphoma · score 0.09
- viral disease · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P23588-F1 | alphafold | PREDICTED | 51.91 | — |
Amino-acid sequence (611 residues)
MAASAKKKNK KGKTISLTDF LAEDGGTGGG STYVSKPVSW ADETDDLEGD VSTTWHSNDD DVYRAPPIDR SILPTAPRAA REPNIDRSRL PKSPPYTAFL GNLPYDVTEE SIKEFFRGLN ISAVRLPREP SNPERLKGFG YAEFEDLDSL LSALSLNEES LGNRRIRVDV ADQAQDKDRD DRSFGRDRNR DSDKTDTDWR ARPATDSFDD YPPRRGDDSF GDKYRDRYDS DRYRDGYRDG YRDGPRRDMD RYGGRDRYDD RGSRDYDRGY DSRIGSGRRA FGSGYRRDDD YRGGGDRYED RYDRRDDRSW SSRDDYSRDD YRRDDRGPPQ RPKLNLKPRS TPKEDDSSAS TSQSTRAASI FGGAKPVDTA AREREVEERL QKEQEKLQRQ LDEPKLERRP RERHPSWRSE ETQERERSRT GSESSQTGTS TTSSRNARRR ESEKSLENET LNKEEDCHSP TSKPPKPDQP LKVMPAPPPK ENAWVKRSSN PPARSQSSDT EQQSPTSGGG KVAPAQPSEE GPGRKDENKV DGMNAPKGQT GNSSRGPGDG GNRDHWKESD RKDGKKDQDS RSAPEPKKPE ENPASKFSSA SKYAALSVDG EDENEGEDYA E
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