40-kDa huntingtin-associated protein (F8A1)

About 40-kDa huntingtin-associated protein

40-kDa huntingtin-associated protein (F8A1) is a protein from Homo sapiens identified by UniProt accession P23610, 371 residues long. MolForge cross-references it against 0 known binders and 10 disease associations.

Target properties

Protein name	40-kDa huntingtin-associated protein
UniProt accession	P23610
Gene	F8A1
Organism	Homo sapiens
Length	371 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (10)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.50
Huntington disease · score 0.01
neoplasm · score 0.01
hemophilia A · score 0.01
venous thromboembolism · score 0.00
neuroblastoma · score 0.00
thrombophilia · score 0.00
Autism · score 0.00
cancer · score 0.00
COVID-19 · score 0.00

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P23610-F1	alphafold	PREDICTED	77.46	—

Amino-acid sequence (371 residues)

MAAAAAGLGG GGAGPGPEAG DFLARYRLVS NKLKKRFLRK PNVAEAGEQF GQLGRELRAQ ECLPYAAWCQ LAVARCQQAL FHGPGEALAL TEAARLFLRQ ERDARQRLVC PAAYGEPLQA AASALGAAVR LHLELGQPAA AAALCLELAA ALRDLGQPAA AAGHFQRAAQ LQLPQLPLAA LQALGEAASC QLLARDYTGA LAVFTRMQRL AREHGSHPVQ SLPPPPPPAP QPGPGATPAL PAALLPPNSG SAAPSPAALG AFSDVLVRCE VSRVLLLLLL QPPPAKLLPE HAQTLEKYSW EAFDSHGQES SGQLPEELFL LLQSLVMATH EKDTEAIKSL QVEMWPLLTA EQNHLLHLVL QETISPSGQG V

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards