Paired box protein Pax-7 (PAX7)

About Paired box protein Pax-7

Paired box protein Pax-7 (PAX7) is a protein from Homo sapiens identified by UniProt accession P23759, 505 residues long. MolForge cross-references it against 0 known binders and 316 disease associations.

Target properties

Protein name	Paired box protein Pax-7
UniProt accession	P23759
Gene	PAX7
Organism	Homo sapiens
Length	505 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (316)

Diseases linked to this target (Open Targets).

myopathy, congenital, progressive, with scoliosis · score 0.66
alveolar rhabdomyosarcoma · score 0.50
rhabdomyosarcoma · score 0.45
cleft lip · score 0.44
cortical surface area measurement · score 0.43
Cleft palate · score 0.40
Orofacial cleft · score 0.39
nose morphology measurement · score 0.39
embryonal rhabdomyosarcoma · score 0.37
desmoplastic small round cell tumor · score 0.37

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P23759-F1	alphafold	PREDICTED	62.00	—

Amino-acid sequence (505 residues)

MAALPGTVPR MMRPAPGQNY PRTGFPLEVS TPLGQGRVNQ LGGVFINGRP LPNHIRHKIV EMAHHGIRPC VISRQLRVSH GCVSKILCRY QETGSIRPGA IGGSKPRQVA TPDVEKKIEE YKRENPGMFS WEIRDRLLKD GHCDRSTVPS GLVSSISRVL RIKFGKKEEE DEADKKEDDG EKKAKHSIDG ILGDKGNRLD EGSDVESEPD LPLKRKQRRS RTTFTAEQLE ELEKAFERTH YPDIYTREEL AQRTKLTEAR VQVWFSNRRA RWRKQAGANQ LAAFNHLLPG GFPPTGMPTL PPYQLPDSTY PTTTISQDGG STVHRPQPLP PSTMHQGGLA AAAAAADTSS AYGARHSFSS YSDSFMNPAA PSNHMNPVSN GLSPQVMSIL GNPSAVPPQP QADFSISPLH GGLDSATSIS ASCSQRADSI KPGDSLPTSQ AYCPPTYSTT GYSVDPVAGY QYGQYGQTAV DYLAKNVSLS TQRRMKLGEH SAVLGLLPVE TGQAY

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards