Paired box protein Pax-3 (PAX3)

About Paired box protein Pax-3

Paired box protein Pax-3 (PAX3) is a protein from Homo sapiens identified by UniProt accession P23760, 479 residues long. MolForge cross-references it against 0 known binders and 542 disease associations.

Target properties

Protein name	Paired box protein Pax-3
UniProt accession	P23760
Gene	PAX3
Organism	Homo sapiens
Length	479 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (542)

Diseases linked to this target (Open Targets).

Waardenburg syndrome type 1 · score 0.84
Waardenburg syndrome type 3 · score 0.78
craniofacial-deafness-hand syndrome · score 0.73
Waardenburg syndrome · score 0.67
alveolar rhabdomyosarcoma · score 0.63
rhabdomyosarcoma · score 0.51
hair shape measurement · score 0.50
Rare genetic deafness · score 0.49
facial morphology measurement · score 0.47
hair color · score 0.47

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P23760-F1	alphafold	PREDICTED	63.94	—

Amino-acid sequence (479 residues)

MTTLAGAVPR MMRPGPGQNY PRSGFPLEVS TPLGQGRVNQ LGGVFINGRP LPNHIRHKIV EMAHHGIRPC VISRQLRVSH GCVSKILCRY QETGSIRPGA IGGSKPKQVT TPDVEKKIEE YKRENPGMFS WEIRDKLLKD AVCDRNTVPS VSSISRILRS KFGKGEEEEA DLERKEAEES EKKAKHSIDG ILSERASAPQ SDEGSDIDSE PDLPLKRKQR RSRTTFTAEQ LEELERAFER THYPDIYTRE ELAQRAKLTE ARVQVWFSNR RARWRKQAGA NQLMAFNHLI PGGFPPTAMP TLPTYQLSET SYQPTSIPQA VSDPSSTVHR PQPLPPSTVH QSTIPSNPDS SSAYCLPSTR HGFSSYTDSF VPPSGPSNPM NPTIGNGLSP QVMGLLTNHG GVPHQPQTDY ALSPLTGGLE PTTTVSASCS QRLDHMKSLD SLPTSQSYCP PTYSTTGYSM DPVTGYQYGQ YGQSKPWTF

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards