Vesicle-associated membrane protein 1 (VAMP1)

About Vesicle-associated membrane protein 1

Vesicle-associated membrane protein 1 (VAMP1) is a protein from Homo sapiens identified by UniProt accession P23763, 118 residues long. MolForge cross-references it against 0 known binders and 61 disease associations.

Target properties

Protein name	Vesicle-associated membrane protein 1
UniProt accession	P23763
Gene	VAMP1
Organism	Homo sapiens
Length	118 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (61)

Diseases linked to this target (Open Targets).

Presynaptic congenital myasthenic syndromes · score 0.71
spastic ataxia 1 · score 0.68
Spastic paraplegia · score 0.53
botulism · score 0.50
congenital myasthenic syndrome · score 0.45
blood protein measurement · score 0.28
neurodegenerative disease · score 0.23
genetic disorder · score 0.12
mean platelet volume · score 0.11
body height · score 0.10

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P23763-F1	alphafold	PREDICTED	74.52	—

Amino-acid sequence (118 residues)

MSAPAQPPAE GTEGTAPGGG PPGPPPNMTS NRRLQQTQAQ VEEVVDIIRV NVDKVLERDQ KLSELDDRAD ALQAGASQFE SSAAKLKRKY WWKNCKMMIM LGAICAIIVV VIVIYFFT

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards