About Endothelial transcription factor GATA-2
Endothelial transcription factor GATA-2 (GATA2) is a protein
from Homo sapiens identified by UniProt accession
P23769, 480 residues long.
MolForge cross-references it against 0 known binders and
621 disease associations.
Target properties
| Protein name | Endothelial transcription factor GATA-2 |
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| UniProt accession | P23769 |
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| Gene | GATA2 |
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| Organism | Homo sapiens |
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| Length | 480 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (621)
Diseases linked to this target (Open Targets).
- monocytopenia with susceptibility to infections · score 0.79
- Deafness - lymphedema - leukemia · score 0.79
- deafness-lymphedema-leukemia syndrome · score 0.79
- myelodysplastic syndrome · score 0.74
- acute myeloid leukemia · score 0.68
- GATA2 deficiency with susceptibility to MDS/AML · score 0.65
- leukemia, acute myeloid, susceptibility to · score 0.62
- neurodegenerative disease · score 0.53
- constitutional neutropenia · score 0.46
- lymphocyte count · score 0.46
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P23769-F1 | alphafold | PREDICTED | 56.38 | — |
Amino-acid sequence (480 residues)
MEVAPEQPRW MAHPAVLNAQ HPDSHHPGLA HNYMEPAQLL PPDEVDVFFN HLDSQGNPYY ANPAHARARV SYSPAHARLT GGQMCRPHLL HSPGLPWLDG GKAALSAAAA HHHNPWTVSP FSKTPLHPSA AGGPGGPLSV YPGAGGGSGG GSGSSVASLT PTAAHSGSHL FGFPPTPPKE VSPDPSTTGA ASPASSSAGG SAARGEDKDG VKYQVSLTES MKMESGSPLR PGLATMGTQP ATHHPIPTYP SYVPAAAHDY SSGLFHPGGF LGGPASSFTP KQRSKARSCS EGRECVNCGA TATPLWRRDG TGHYLCNACG LYHKMNGQNR PLIKPKRRLS AARRAGTCCA NCQTTTTTLW RRNANGDPVC NACGLYYKLH NVNRPLTMKK EGIQTRNRKM SNKSKKSKKG AECFEELSKC MQEKSSPFSA AALAGHMAPV GHLPPFSHSG HILPTPTPIH PSSSLSFGHP HPSSMVTAMG
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