About Trans-acting T-cell-specific transcription factor GATA-3
Trans-acting T-cell-specific transcription factor GATA-3 (GATA3) is a protein
from Homo sapiens identified by UniProt accession
P23771, 443 residues long.
MolForge cross-references it against 0 known binders and
1,271 disease associations.
Target properties
| Protein name | Trans-acting T-cell-specific transcription factor GATA-3 |
|---|
| UniProt accession | P23771 |
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| Gene | GATA3 |
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| Organism | Homo sapiens |
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| Length | 443 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (1271)
Diseases linked to this target (Open Targets).
- hypoparathyroidism-deafness-renal disease syndrome · score 0.81
- Hypoparathyroidism - deafness - renal disease · score 0.79
- breast adenocarcinoma · score 0.61
- neurodegenerative disease · score 0.53
- eosinophil count · score 0.48
- asthma · score 0.48
- B-cell acute lymphoblastic leukemia · score 0.47
- genetic disorder · score 0.45
- breast carcinoma · score 0.44
- congenital anomaly of kidney and urinary tract · score 0.43
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P23771-F1 | alphafold | PREDICTED | 58.13 | — |
Amino-acid sequence (443 residues)
MEVTADQPRW VSHHHPAVLN GQHPDTHHPG LSHSYMDAAQ YPLPEEVDVL FNIDGQGNHV PPYYGNSVRA TVQRYPPTHH GSQVCRPPLL HGSLPWLDGG KALGSHHTAS PWNLSPFSKT SIHHGSPGPL SVYPPASSSS LSGGHASPHL FTFPPTPPKD VSPDPSLSTP GSAGSARQDE KECLKYQVPL PDSMKLESSH SRGSMTALGG ASSSTHHPIT TYPPYVPEYS SGLFPPSSLL GGSPTGFGCK SRPKARSSTG RECVNCGATS TPLWRRDGTG HYLCNACGLY HKMNGQNRPL IKPKRRLSAA RRAGTSCANC QTTTTTLWRR NANGDPVCNA CGLYYKLHNI NRPLTMKKEG IQTRNRKMSS KSKKCKKVHD SLEDFPKNSS FNPAALSRHM SSLSHISPFS HSSHMLTTPT PMHPPSSLSF GPHHPSSMVT AMG
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