About Carnitine O-palmitoyltransferase 2, mitochondrial
Carnitine O-palmitoyltransferase 2, mitochondrial (CPT2) is a protein
from Homo sapiens identified by UniProt accession
P23786, 658 residues long.
MolForge cross-references it against 0 known binders and
260 disease associations.
Target properties
| Protein name | Carnitine O-palmitoyltransferase 2, mitochondrial |
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| UniProt accession | P23786 |
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| Gene | CPT2 |
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| Organism | Homo sapiens |
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| Length | 658 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (1)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (260)
Diseases linked to this target (Open Targets).
- carnitine palmitoyl transferase II deficiency, myopathic form · score 0.83
- carnitine palmitoyl transferase II deficiency, severe infantile form · score 0.80
- carnitine palmitoyl transferase II deficiency, neonatal form · score 0.76
- carnitine palmitoyltransferase II deficiency · score 0.67
- genetic disorder · score 0.41
- cardiovascular disease · score 0.37
- Gastrointestinal dysmotility · score 0.34
- Abnormal autonomic nervous system physiology · score 0.34
- Abnormality of the nervous system · score 0.34
- Seizure · score 0.34
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P23786-F1 | alphafold | PREDICTED | 94.13 | — |
Amino-acid sequence (658 residues)
MVPRLLLRAW PRGPAVGPGA PSRPLSAGSG PGQYLQRSIV PTMHYQDSLP RLPIPKLEDT IRRYLSAQKP LLNDGQFRKT EQFCKSFENG IGKELHEQLV ALDKQNKHTS YISGPWFDMY LSARDSVVLN FNPFMAFNPD PKSEYNDQLT RATNMTVSAI RFLKTLRAGL LEPEVFHLNP AKSDTITFKR LIRFVPSSLS WYGAYLVNAY PLDMSQYFRL FNSTRLPKPS RDELFTDDKA RHLLVLRKGN FYIFDVLDQD GNIVSPSEIQ AHLKYILSDS SPAPEFPLAY LTSENRDIWA ELRQKLMSSG NEESLRKVDS AVFCLCLDDF PIKDLVHLSH NMLHGDGTNR WFDKSFNLII AKDGSTAVHF EHSWGDGVAV LRFFNEVFKD STQTPAVTPQ SQPATTDSTV TVQKLNFELT DALKTGITAA KEKFDATMKT LTIDCVQFQR GGKEFLKKQK LSPDAVAQLA FQMAFLRQYG QTVATYESCS TAAFKHGRTE TIRPASVYTK RCSEAFVREP SRHSAGELQQ MMVECSKYHG QLTKEAAMGQ GFDRHLFALR HLAAAKGIIL PELYLDPAYG QINHNVLSTS TLSSPAVNLG GFAPVVSDGF GVGYAVHDNW IGCNVSSYPG RNAREFLQCV EKALEDMFDA LEGKSIKS
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