About Thymidylate kinase
Thymidylate kinase (DTYMK) is a protein
from Homo sapiens identified by UniProt accession
P23919, 212 residues long.
MolForge cross-references it against 0 known binders and
85 disease associations.
Target properties
| Protein name | Thymidylate kinase |
|---|
| UniProt accession | P23919 |
|---|
| Gene | DTYMK |
|---|
| Organism | Homo sapiens |
|---|
| Length | 212 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Approved drugs hitting this target (1)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (85)
Diseases linked to this target (Open Targets).
- neurodegeneration, childhood-onset, with progressive microcephaly · score 0.66
- neurodegenerative disease · score 0.55
- Microcephaly · score 0.47
- microcephaly · score 0.46
- Seizure · score 0.46
- Global developmental delay · score 0.46
- Intellectual disability · score 0.46
- Global brain atrophy · score 0.46
- platelet count · score 0.22
- mean platelet volume · score 0.16
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P23919-F1 | alphafold | PREDICTED | 95.61 | — |
Amino-acid sequence (212 residues)
MAARRGALIV LEGVDRAGKS TQSRKLVEAL CAAGHRAELL RFPERSTEIG KLLSSYLQKK SDVEDHSVHL LFSANRWEQV PLIKEKLSQG VTLVVDRYAF SGVAFTGAKE NFSLDWCKQP DVGLPKPDLV LFLQLQLADA AKRGAFGHER YENGAFQERA LRCFHQLMKD TTLNWKMVDA SKSIEAVHED IRVLSEDAIR TATEKPLGEL WK
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