Peripherin-2 (PRPH2)

About Peripherin-2

Peripherin-2 (PRPH2) is a protein from Homo sapiens identified by UniProt accession P23942, 346 residues long. MolForge cross-references it against 0 known binders and 334 disease associations.

Target properties

Protein name	Peripherin-2
UniProt accession	P23942
Gene	PRPH2
Organism	Homo sapiens
Length	346 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (334)

Diseases linked to this target (Open Targets).

patterned macular dystrophy 1 · score 0.75
vitelliform macular dystrophy 3 · score 0.75
choroidal dystrophy, central areolar 2 · score 0.72
Butterfly-shaped pigment dystrophy · score 0.71
retinitis pigmentosa · score 0.69
retinopathy · score 0.68
Cone rod dystrophy · score 0.63
macular degeneration · score 0.58
Macular dystrophy · score 0.58
adult-onset foveomacular vitelliform dystrophy · score 0.58

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P23942-F1	alphafold	PREDICTED	87.00	—

Amino-acid sequence (346 residues)

MALLKVKFDQ KKRVKLAQGL WLMNWFSVLA GIIIFSLGLF LKIELRKRSD VMNNSESHFV PNSLIGMGVL SCVFNSLAGK ICYDALDPAK YARWKPWLKP YLAICVLFNI ILFLVALCCF LLRGSLENTL GQGLKNGMKY YRDTDTPGRC FMKKTIDMLQ IEFKCCGNNG FRDWFEIQWI SNRYLDFSSK EVKDRIKSNV DGRYLVDGVP FSCCNPSSPR PCIQYQITNN SAHYSYDHQT EELNLWVRGC RAALLSYYSS LMNSMGVVTL LIWLFEVTIT IGLRYLQTSL DGVSNPEESE SESQGWLLER SVPETWKAFL ESVKKLGKGN QVEAEGADAG QAPEAG

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards