About Chymase
Chymase (CMA1) is a protein
from Homo sapiens identified by UniProt accession
P23946, 247 residues long.
MolForge cross-references it against 0 known binders and
360 disease associations.
Target properties
| Protein name | Chymase |
|---|
| UniProt accession | P23946 |
|---|
| Gene | CMA1 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 247 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Approved drugs hitting this target (3)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (360)
Diseases linked to this target (Open Targets).
- cutaneous melanoma · score 0.19
- thyroid gland adenocarcinoma · score 0.18
- lung adenocarcinoma · score 0.17
- squamous cell lung carcinoma · score 0.10
- glioblastoma multiforme · score 0.10
- head and neck squamous cell carcinoma · score 0.10
- dengue disease · score 0.10
- myocardial infarction · score 0.09
- Dengue Hemorrhagic Fever · score 0.08
- melanoma · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P23946-F1 | alphafold | PREDICTED | 91.33 | — |
Amino-acid sequence (247 residues)
MLLLPLPLLL FLLCSRAEAG EIIGGTECKP HSRPYMAYLE IVTSNGPSKF CGGFLIRRNF VLTAAHCAGR SITVTLGAHN ITEEEDTWQK LEVIKQFRHP KYNTSTLHHD IMLLKLKEKA SLTLAVGTLP FPSQFNFVPP GRMCRVAGWG RTGVLKPGSD TLQEVKLRLM DPQACSHFRD FDHNLQLCVG NPRKTKSAFK GDSGGPLLCA GVAQGIVSYG RSDAKPPAVF TRISHYRPWI NQILQAN
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