About Immunoglobulin alpha Fc receptor
Immunoglobulin alpha Fc receptor (FCAR) is a protein
from Homo sapiens identified by UniProt accession
P24071, 287 residues long.
MolForge cross-references it against 0 known binders and
115 disease associations.
Target properties
| Protein name | Immunoglobulin alpha Fc receptor |
|---|
| UniProt accession | P24071 |
|---|
| Gene | FCAR |
|---|
| Organism | Homo sapiens |
|---|
| Length | 287 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (115)
Diseases linked to this target (Open Targets).
- killer cell immunoglobulin-like receptor 2DL4 measurement · score 0.26
- ulcerative colitis · score 0.17
- inflammatory bowel disease · score 0.11
- IGA glomerulonephritis · score 0.10
- neoplasm · score 0.10
- total blood protein measurement · score 0.09
- Sepsis · score 0.06
- colorectal adenocarcinoma · score 0.04
- Crohn's disease · score 0.03
- psoriasis · score 0.03
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P24071-F1 | alphafold | PREDICTED | 83.58 | — |
Amino-acid sequence (287 residues)
MDPKQTTLLC LVLCLGQRIQ AQEGDFPMPF ISAKSSPVIP LDGSVKIQCQ AIREAYLTQL MIIKNSTYRE IGRRLKFWNE TDPEFVIDHM DANKAGRYQC QYRIGHYRFR YSDTLELVVT GLYGKPFLSA DRGLVLMPGE NISLTCSSAH IPFDRFSLAK EGELSLPQHQ SGEHPANFSL GPVDLNVSGI YRCYGWYNRS PYLWSFPSNA LELVVTDSIH QDYTTQNLIR MAVAGLVLVA LLAILVENWH SHTALNKEAS ADVAEPSWSQ QMCQPGLTFA RTPSVCK
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