Zinc finger and BTB domain-containing protein 25 (ZBTB25)

About Zinc finger and BTB domain-containing protein 25

Zinc finger and BTB domain-containing protein 25 (ZBTB25) is a protein from Homo sapiens identified by UniProt accession P24278, 435 residues long. MolForge cross-references it against 0 known binders and 33 disease associations.

Target properties

Protein name	Zinc finger and BTB domain-containing protein 25
UniProt accession	P24278
Gene	ZBTB25
Organism	Homo sapiens
Length	435 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (33)

Diseases linked to this target (Open Targets).

lymphocyte count · score 0.34
severe combined immunodeficiency · score 0.33
self reported educational attainment · score 0.32
lymphocyte percentage of leukocytes · score 0.32
platelet count · score 0.30
neutrophil percentage of leukocytes · score 0.28
heel bone mineral density · score 0.28
neutrophil-to-lymphocyte ratio · score 0.23
Eczematoid dermatitis · score 0.22
mean corpuscular volume · score 0.18

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P24278-F1	alphafold	PREDICTED	58.60	—

Amino-acid sequence (435 residues)

MDTASHSLVL LQQLNMQREF GFLCDCTVAI GDVYFKAHRA VLAAFSNYFK MIFIHQTSEC IKIQPTDIQP DIFSYLLHIM YTGKGPKQIV DHSRLEEGIR FLHADYLSHI ATEMNQVFSP ETVQSSNLYG IQISTTQKTV VKQGLEVKEA PSSNSGNRAA VQGDHPQLQL SLAIGLDDGT ADQQRACPAT QALEEHQKPP VSIKQERCDP ESVISQSHPS PSSEVTGPTF TENSVKIHLC HYCGERFDSR SNLRQHLHTH VSGSLPFGVP ASILESNDLG EVHPLNENSE ALECRRLSSF IVKENEQQPD HTNRGTTEPL QISQVSLISK DTEPVELNCN FSFSRKRKMS CTICGHKFPR KSQLLEHMYT HKGKSYRYNR CQRFGNALAQ RFQPYCDSWS DVSLKSSRLS QEHLDLPCAL ESELTQENVD TILVE

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards