About Alanine aminotransferase 1
Alanine aminotransferase 1 (GPT) is a protein
from Homo sapiens identified by UniProt accession
P24298, 496 residues long.
MolForge cross-references it against 0 known binders and
1,646 disease associations.
Target properties
| Protein name | Alanine aminotransferase 1 |
|---|
| UniProt accession | P24298 |
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| Gene | GPT |
|---|
| Organism | Homo sapiens |
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| Length | 496 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
|---|
Disease associations (1646)
Diseases linked to this target (Open Targets).
- serum alanine aminotransferase measurement · score 0.65
- neurodegenerative disease · score 0.26
- mean corpuscular hemoglobin concentration · score 0.15
- Red cell distribution width · score 0.13
- type 2 diabetes mellitus · score 0.12
- hepatocellular carcinoma · score 0.12
- non-alcoholic fatty liver disease · score 0.12
- neoplasm · score 0.12
- metabolic syndrome · score 0.12
- insulin resistance · score 0.12
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P24298-F1 | alphafold | PREDICTED | 95.15 | — |
Amino-acid sequence (496 residues)
MASSTGDRSQ AVRHGLRAKV LTLDGMNPRV RRVEYAVRGP IVQRALELEQ ELRQGVKKPF TEVIRANIGD AQAMGQRPIT FLRQVLALCV NPDLLSSPNF PDDAKKRAER ILQACGGHSL GAYSVSSGIQ LIREDVARYI ERRDGGIPAD PNNVFLSTGA SDAIVTVLKL LVAGEGHTRT GVLIPIPQYP LYSATLAELG AVQVDYYLDE ERAWALDVAE LHRALGQARD HCRPRALCVI NPGNPTGQVQ TRECIEAVIR FAFEERLFLL ADEVYQDNVY AAGSQFHSFK KVLMEMGPPY AGQQELASFH STSKGYMGEC GFRGGYVEVV NMDAAVQQQM LKLMSVRLCP PVPGQALLDL VVSPPAPTDP SFAQFQAEKQ AVLAELAAKA KLTEQVFNEA PGISCNPVQG AMYSFPRVQL PPRAVERAQE LGLAPDMFFC LRLLEETGIC VVPGSGFGQR EGTYHFRMTI LPPLEKLRLL LEKLSRFHAK FTLEYS
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