Stromelysin-3 (MMP11)

About Stromelysin-3

Stromelysin-3 (MMP11) is a protein from Homo sapiens identified by UniProt accession P24347, 488 residues long. MolForge cross-references it against 0 known binders and 267 disease associations.

Target properties

Protein name	Stromelysin-3
UniProt accession	P24347
Gene	MMP11
Organism	Homo sapiens
Length	488 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (267)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.42
ulcerative colitis · score 0.26
lung adenocarcinoma · score 0.25
breast adenocarcinoma · score 0.23
serum IgG glycosylation measurement · score 0.17
cutaneous melanoma · score 0.15
creatinine measurement · score 0.15
left ventricular systolic function measurement · score 0.11
ejection fraction measurement · score 0.11
neoplasm · score 0.11

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P24347-F1	alphafold	PREDICTED	77.21	—

Amino-acid sequence (488 residues)

MAPAAWLRSA AARALLPPML LLLLQPPPLL ARALPPDAHH LHAERRGPQP WHAALPSSPA PAPATQEAPR PASSLRPPRC GVPDPSDGLS ARNRQKRFVL SGGRWEKTDL TYRILRFPWQ LVQEQVRQTM AEALKVWSDV TPLTFTEVHE GRADIMIDFA RYWHGDDLPF DGPGGILAHA FFPKTHREGD VHFDYDETWT IGDDQGTDLL QVAAHEFGHV LGLQHTTAAK ALMSAFYTFR YPLSLSPDDC RGVQHLYGQP WPTVTSRTPA LGPQAGIDTN EIAPLEPDAP PDACEASFDA VSTIRGELFF FKAGFVWRLR GGQLQPGYPA LASRHWQGLP SPVDAAFEDA QGHIWFFQGA QYWVYDGEKP VLGPAPLTEL GLVRFPVHAA LVWGPEKNKI YFFRGRDYWR FHPSTRRVDS PVPRRATDWR GVPSEIDAAF QDADGYAYFL RGRLYWKFDP VKVKALEGFP RLVGPDFFGC AEPANTFL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards