About G1/S-specific cyclin-D1
G1/S-specific cyclin-D1 (CCND1) is a protein
from Homo sapiens identified by UniProt accession
P24385, 295 residues long.
MolForge cross-references it against 0 known binders and
1,170 disease associations.
Target properties
| Protein name | G1/S-specific cyclin-D1 |
|---|
| UniProt accession | P24385 |
|---|
| Gene | CCND1 |
|---|
| Organism | Homo sapiens |
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| Length | 295 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (1170)
Diseases linked to this target (Open Targets).
- multiple myeloma · score 0.58
- neurodegenerative disease · score 0.53
- cutaneous melanoma · score 0.49
- breast carcinoma · score 0.48
- type 2 diabetes mellitus · score 0.48
- AL amyloidosis · score 0.46
- serum gamma-glutamyl transferase measurement · score 0.44
- endometrial cancer · score 0.44
- body mass index · score 0.44
- IgG isotype profile measurement · score 0.43
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P24385-F1 | alphafold | PREDICTED | 87.32 | — |
Amino-acid sequence (295 residues)
MEHQLLCCEV ETIRRAYPDA NLLNDRVLRA MLKAEETCAP SVSYFKCVQK EVLPSMRKIV ATWMLEVCEE QKCEEEVFPL AMNYLDRFLS LEPVKKSRLQ LLGATCMFVA SKMKETIPLT AEKLCIYTDN SIRPEELLQM ELLLVNKLKW NLAAMTPHDF IEHFLSKMPE AEENKQIIRK HAQTFVALCA TDVKFISNPP SMVAAGSVVA AVQGLNLRSP NNFLSYYRLT RFLSRVIKCD PDCLRACQEQ IEALLESSLR QAQQNMDPKA AEEEEEEEEE VDLACTPTDV RDVDI
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