Corticotropin-releasing factor-binding protein (CRHBP)

About Corticotropin-releasing factor-binding protein

Corticotropin-releasing factor-binding protein (CRHBP) is a protein from Homo sapiens identified by UniProt accession P24387, 322 residues long. MolForge cross-references it against 0 known binders and 96 disease associations.

Target properties

Protein name	Corticotropin-releasing factor-binding protein
UniProt accession	P24387
Gene	CRHBP
Organism	Homo sapiens
Length	322 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (96)

Diseases linked to this target (Open Targets).

blood protein measurement · score 0.16
drug use measurement · score 0.12
hepatocellular carcinoma · score 0.11
low grade glioma · score 0.10
neoplasm · score 0.10
nonpapillary renal cell carcinoma · score 0.08
cancer · score 0.07
renal cell carcinoma · score 0.06
Varicose veins · score 0.06
bulimia nervosa · score 0.05

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P24387-F1	alphafold	PREDICTED	83.53	—

Amino-acid sequence (322 residues)

MSPNFKLQCH FILIFLTALR GESRYLELRE AADYDPFLLF SANLKRELAG EQPYRRALRC LDMLSLQGQF TFTADRPQLH CAAFFISEPE EFITIHYDQV SIDCQGGDFL KVFDGWILKG EKFPSSQDHP LPSAERYIDF CESGLSRRSI RSSQNVAMIF FRVHEPGNGF TLTIKTDPNL FPCNVISQTP NGKFTLVVPH QHRNCSFSII YPVVIKISDL TLGHVNGLQL KKSSAGCEGI GDFVELLGGT GLDPSKMTPL ADLCYPFHGP AQMKVGCDNT VVRMVSSGKH VNRVTFEYRQ LEPYELENPN GNSIGEFCLS GL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards