ER lumen protein-retaining receptor 1 (KDELR1)

About ER lumen protein-retaining receptor 1

ER lumen protein-retaining receptor 1 (KDELR1) is a protein from Homo sapiens identified by UniProt accession P24390, 212 residues long. MolForge cross-references it against 0 known binders and 168 disease associations.

Target properties

Protein name	ER lumen protein-retaining receptor 1
UniProt accession	P24390
Gene	KDELR1
Organism	Homo sapiens
Length	212 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (168)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.31
pancreatic adenocarcinoma · score 0.21
ovarian carcinoma · score 0.17
breast adenocarcinoma · score 0.10
Okt4 epitope deficiency · score 0.07
common variable immunodeficiency · score 0.07
severe combined immunodeficiency due to IKK2 deficiency · score 0.07
isolated agammaglobulinemia · score 0.07
combined immunodeficiency with skin granulomas · score 0.07
Chronic mucocutaneous candidosis · score 0.06

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P24390-F1	alphafold	PREDICTED	92.50	—

Amino-acid sequence (212 residues)

MNLFRFLGDL SHLLAIILLL LKIWKSRSCA GISGKSQVLF AVVFTARYLD LFTNYISLYN TCMKVVYIAC SFTTVWLIYS KFKATYDGNH DTFRVEFLVV PTAILAFLVN HDFTPLEILW TFSIYLESVA ILPQLFMVSK TGEAETITSH YLFALGVYRT LYLFNWIWRY HFEGFFDLIA IVAGLVQTVL YCDFFYLYIT KVLKGKKLSL PA

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards