Cytochrome P450 3A7 (CYP3A7)

About Cytochrome P450 3A7

Cytochrome P450 3A7 (CYP3A7) is a protein from Homo sapiens identified by UniProt accession P24462, 503 residues long. MolForge cross-references it against 0 known binders and 132 disease associations.

Target properties

Protein name	Cytochrome P450 3A7
UniProt accession	P24462
Gene	CYP3A7
Organism	Homo sapiens
Length	503 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (132)

Diseases linked to this target (Open Targets).

HIV infection · score 0.61
HIV-1 infection · score 0.60
COVID-19 · score 0.58
AIDS · score 0.58
chronic hepatitis C virus infection · score 0.57
infection · score 0.55
hepatitis C virus infection · score 0.55
HIV-Associated Lipodystrophy Syndrome · score 0.46
coronavirus infectious disease · score 0.43
cancer · score 0.40

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P24462-F1	alphafold	PREDICTED	92.29	—

Amino-acid sequence (503 residues)

MDLIPNLAVE TWLLLAVSLI LLYLYGTRTH GLFKKLGIPG PTPLPFLGNA LSFRKGYWTF DMECYKKYRK VWGIYDCQQP MLAITDPDMI KTVLVKECYS VFTNRRPFGP VGFMKNAISI AEDEEWKRIR SLLSPTFTSG KLKEMVPIIA QYGDVLVRNL RREAETGKPV TLKHVFGAYS MDVITSTSFG VSIDSLNNPQ DPFVENTKKL LRFNPLDPFV LSIKVFPFLT PILEALNITV FPRKVISFLT KSVKQIKEGR LKETQKHRVD FLQLMIDSQN SKDSETHKAL SDLELMAQSI IFIFAGYETT SSVLSFIIYE LATHPDVQQK VQKEIDTVLP NKAPPTYDTV LQLEYLDMVV NETLRLFPVA MRLERVCKKD VEINGMFIPK GVVVMIPSYV LHHDPKYWTE PEKFLPERFS KKNKDNIDPY IYTPFGSGPR NCIGMRFALV NMKLALVRVL QNFSFKPCKE TQIPLKLRFG GLLLTEKPIV LKAESRDETV SGA

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards