COUP transcription factor 2 (NR2F2)

About COUP transcription factor 2

COUP transcription factor 2 (NR2F2) is a protein from Homo sapiens identified by UniProt accession P24468, 414 residues long. MolForge cross-references it against 0 known binders and 360 disease associations.

Target properties

Protein name	COUP transcription factor 2
UniProt accession	P24468
Gene	NR2F2
Organism	Homo sapiens
Length	414 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (360)

Diseases linked to this target (Open Targets).

congenital heart disease · score 0.73
46,xx sex reversal 5 · score 0.58
neurodegenerative disease · score 0.54
genetic disorder · score 0.50
sex hormone-binding globulin measurement · score 0.42
Parkinson disease · score 0.31
cortical surface area measurement · score 0.31
Alzheimer disease · score 0.30
lysosomal storage disease · score 0.30
multiple sclerosis · score 0.30

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P24468-F1	alphafold	PREDICTED	76.75	—

Amino-acid sequence (414 residues)

MAMVVSTWRD PQDEVPGSQG SQASQAPPVP GPPPGAPHTP QTPGQGGPAS TPAQTAAGGQ GGPGGPGSDK QQQQQHIECV VCGDKSSGKH YGQFTCEGCK SFFKRSVRRN LSYTCRANRN CPIDQHHRNQ CQYCRLKKCL KVGMRREAVQ RGRMPPTQPT HGQFALTNGD PLNCHSYLSG YISLLLRAEP YPTSRFGSQC MQPNNIMGIE NICELAARML FSAVEWARNI PFFPDLQITD QVALLRLTWS ELFVLNAAQC SMPLHVAPLL AAAGLHASPM SADRVVAFMD HIRIFQEQVE KLKALHVDSA EYSCLKAIVL FTSDACGLSD VAHVESLQEK SQCALEEYVR SQYPNQPTRF GKLLLRLPSL RTVSSSVIEQ LFFVRLVGKT PIETLIRDML LSGSSFNWPY MAIQ

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards