Growth arrest and DNA damage-inducible protein…

About Growth arrest and DNA damage-inducible protein GADD45 alpha

Growth arrest and DNA damage-inducible protein GADD45 alpha (GADD45A) is a protein from Homo sapiens identified by UniProt accession P24522, 165 residues long. MolForge cross-references it against 0 known binders and 332 disease associations.

Target properties

Protein name	Growth arrest and DNA damage-inducible protein GADD45 alpha
UniProt accession	P24522
Gene	GADD45A
Organism	Homo sapiens
Length	165 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (332)

Diseases linked to this target (Open Targets).

platelet count · score 0.40
mean corpuscular volume · score 0.38
monocyte count · score 0.36
facial morphology measurement · score 0.36
C-reactive protein measurement · score 0.35
FEV/FVC ratio · score 0.34
red blood cell density measurement · score 0.34
platelet crit · score 0.33
alkaline phosphatase measurement · score 0.32
erythrocyte count · score 0.31

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P24522-F1	alphafold	PREDICTED	81.23	—

Amino-acid sequence (165 residues)

MTLEEFSAGE QKTERMDKVG DALEEVLSKA LSQRTITVGV YEAAKLLNVD PDNVVLCLLA ADEDDDRDVA LQIHFTLIQA FCCENDINIL RVSNPGRLAE LLLLETDAGP AASEGAEQPP DLHCVLVTNP HSSQWKDPAL SQLICFCRES RYMDQWVPVI NLPER

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards

Growth arrest and DNA damage-inducible protein GADD45 alpha (GADD45A)