About A-kinase anchor protein 5
A-kinase anchor protein 5 (AKAP5) is a protein
from Homo sapiens identified by UniProt accession
P24588, 427 residues long.
MolForge cross-references it against 0 known binders and
82 disease associations.
Target properties
| Protein name | A-kinase anchor protein 5 |
|---|
| UniProt accession | P24588 |
|---|
| Gene | AKAP5 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 427 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (82)
Diseases linked to this target (Open Targets).
- mean corpuscular volume · score 0.22
- platelet count · score 0.17
- testosterone measurement · score 0.13
- MODY · score 0.10
- mean corpuscular hemoglobin · score 0.09
- heel bone mineral density · score 0.08
- type 2 diabetes mellitus · score 0.08
- lymphocyte count · score 0.08
- hyperinsulinism due to INSR deficiency · score 0.07
- type 1 diabetes mellitus · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P24588-F1 | alphafold | PREDICTED | 54.26 | — |
Amino-acid sequence (427 residues)
METTISEIHV ENKDEKRSAE GSPGAERQKE KASMLCFKRR KKAAKALKPK AGSEAADVAR KCPQEAGASD QPEPTRGAWA SLKRLVTRRK RSESSKQQKP LEGEMQPAIN AEDADLSKKK AKSRLKIPCI KFPRGPKRSN HSKIIEDSDC SIKVQEEAEI LDIQTQTPLN DQATKAKSTQ DLSEGISRKD GDEVCESNVS NSTTSGEKVI SVELGLDNGH SAIQTGTLIL EEIETIKEKQ DVQPQQASPL ETSETDHQQP VLSDVPPLPA IPDQQIVEEA SNSTLESAPN GKDYESTEIV AEETKPKDTE LSQESDFKEN GITEEKSKSE ESKRMEPIAI IITDTEISEF DVTKSKNVPK QFLISAENEQ VGVFANDNGF EDRTSEQYET LLIETASSLV KNAIQLSIEQ LVNEMASDDN KINNLLQ
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