About Insulin-like growth factor-binding protein 6
Insulin-like growth factor-binding protein 6 (IGFBP6) is a protein
from Homo sapiens identified by UniProt accession
P24592, 240 residues long.
MolForge cross-references it against 0 known binders and
171 disease associations.
Target properties
| Protein name | Insulin-like growth factor-binding protein 6 |
|---|
| UniProt accession | P24592 |
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| Gene | IGFBP6 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 240 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (171)
Diseases linked to this target (Open Targets).
- IGF-1 measurement · score 0.28
- cutaneous melanoma · score 0.19
- pancreatic adenocarcinoma · score 0.16
- glioblastoma multiforme · score 0.09
- neoplasm · score 0.09
- breast cancer · score 0.08
- Rheumatoid arthritis · score 0.08
- cystic fibrosis · score 0.07
- appendicular lean mass · score 0.06
- type 1 diabetes mellitus · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P24592-F1 | alphafold | PREDICTED | 70.31 | — |
Amino-acid sequence (240 residues)
MTPHRLLPPL LLLLALLLAA SPGGALARCP GCGQGVQAGC PGGCVEEEDG GSPAEGCAEA EGCLRREGQE CGVYTPNCAP GLQCHPPKDD EAPLRALLLG RGRCLPARAP AVAEENPKES KPQAGTARPQ DVNRRDQQRN PGTSTTPSQP NSAGVQDTEM GPCRRHLDSV LQQLQTEVYR GAQTLYVPNC DHRGFYRKRQ CRSSQGQRRG PCWCVDRMGK SLPGSPDGNG SSSCPTGSSG
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