Insulin-like growth factor-binding protein 5 (IGFBP5)

About Insulin-like growth factor-binding protein 5

Insulin-like growth factor-binding protein 5 (IGFBP5) is a protein from Homo sapiens identified by UniProt accession P24593, 272 residues long. MolForge cross-references it against 0 known binders and 308 disease associations.

Target properties

Protein name	Insulin-like growth factor-binding protein 5
UniProt accession	P24593
Gene	IGFBP5
Organism	Homo sapiens
Length	272 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (308)

Diseases linked to this target (Open Targets).

refractive error measurement · score 0.40
FEV/FVC ratio · score 0.33
appendicular lean mass · score 0.33
thyroid stimulating hormone measurement · score 0.33
blood protein measurement · score 0.32
hormone measurement · score 0.30
PR interval · score 0.25
corneal topography · score 0.24
inflammatory bowel disease · score 0.24
hypothyroidism · score 0.24

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P24593-F1	alphafold	PREDICTED	76.07	—

Amino-acid sequence (272 residues)

MVLLTAVLLL LAAYAGPAQS LGSFVHCEPC DEKALSMCPP SPLGCELVKE PGCGCCMTCA LAEGQSCGVY TERCAQGLRC LPRQDEEKPL HALLHGRGVC LNEKSYREQV KIERDSREHE EPTTSEMAEE TYSPKIFRPK HTRISELKAE AVKKDRRKKL TQSKFVGGAE NTAHPRIISA PEMRQESEQG PCRRHMEASL QELKASPRMV PRAVYLPNCD RKGFYKRKQC KPSRGRKRGI CWCVDKYGMK LPGMEYVDGD FQCHTFDSSN VE

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards