About Acetyl-CoA acetyltransferase, mitochondrial
Acetyl-CoA acetyltransferase, mitochondrial (ACAT1) is a protein
from Homo sapiens identified by UniProt accession
P24752, 427 residues long.
MolForge cross-references it against 0 known binders and
116 disease associations.
Target properties
| Protein name | Acetyl-CoA acetyltransferase, mitochondrial |
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| UniProt accession | P24752 |
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| Gene | ACAT1 |
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| Organism | Homo sapiens |
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| Length | 427 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (2)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (116)
Diseases linked to this target (Open Targets).
- beta-ketothiolase deficiency · score 0.83
- genetic disorder · score 0.47
- reticulocyte count · score 0.20
- benign neoplasm · score 0.11
- mean reticulocyte volume · score 0.10
- rheumatoid arthritis · score 0.10
- neoplasm · score 0.10
- eosinophil percentage of leukocytes · score 0.08
- eosinophil count · score 0.08
- nonpapillary renal cell carcinoma · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P24752-F1 | alphafold | PREDICTED | 95.35 | — |
Amino-acid sequence (427 residues)
MAVLAALLRS GARSRSPLLR RLVQEIRYVE RSYVSKPTLK EVVIVSATRT PIGSFLGSLS LLPATKLGSI AIQGAIEKAG IPKEEVKEAY MGNVLQGGEG QAPTRQAVLG AGLPISTPCT TINKVCASGM KAIMMASQSL MCGHQDVMVA GGMESMSNVP YVMNRGSTPY GGVKLEDLIV KDGLTDVYNK IHMGSCAENT AKKLNIARNE QDAYAINSYT RSKAAWEAGK FGNEVIPVTV TVKGQPDVVV KEDEEYKRVD FSKVPKLKTV FQKENGTVTA ANASTLNDGA AALVLMTADA AKRLNVTPLA RIVAFADAAV EPIDFPIAPV YAASMVLKDV GLKKEDIAMW EVNEAFSLVV LANIKMLEID PQKVNINGGA VSLGHPIGMS GARIVGHLTH ALKQGEYGLA SICNGGGGAS AMLIQKL
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