Deoxyribonuclease-1 (DNASE1)

About Deoxyribonuclease-1

Deoxyribonuclease-1 (DNASE1) is a protein from Homo sapiens identified by UniProt accession P24855, 282 residues long. MolForge cross-references it against 0 known binders and 340 disease associations.

Target properties

Protein name	Deoxyribonuclease-1
UniProt accession	P24855
Gene	DNASE1
Organism	Homo sapiens
Length	282 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (340)

Diseases linked to this target (Open Targets).

systemic lupus erythematosus · score 0.46
Autosomal recessive systemic lupus erythematosus · score 0.37
neutrophil count · score 0.36
congenital hydronephrosis · score 0.34
congenital anomaly of kidney and urinary tract · score 0.33
congenital anomalies of kidney and urinary tract 1 · score 0.33
myeloid white cell count · score 0.31
vital capacity · score 0.31
forced expiratory volume · score 0.30
body mass index · score 0.29

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P24855-F1	alphafold	PREDICTED	94.24	—

Amino-acid sequence (282 residues)

MRGMKLLGAL LALAALLQGA VSLKIAAFNI QTFGETKMSN ATLVSYIVQI LSRYDIALVQ EVRDSHLTAV GKLLDNLNQD APDTYHYVVS EPLGRNSYKE RYLFVYRPDQ VSAVDSYYYD DGCEPCGNDT FNREPAIVRF FSRFTEVREF AIVPLHAAPG DAVAEIDALY DVYLDVQEKW GLEDVMLMGD FNAGCSYVRP SQWSSIRLWT SPTFQWLIPD SADTTATPTH CAYDRIVVAG MLLRGAVVPD SALPFNFQAA YGLSDQLAQA ISDHYPVEVM LK

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards