C-X-C chemokine receptor type 2 (CXCR2)

About C-X-C chemokine receptor type 2

C-X-C chemokine receptor type 2 (CXCR2) is a protein from Homo sapiens identified by UniProt accession P25025, 360 residues long. MolForge cross-references it against 0 known binders and 951 disease associations.

Target properties

Protein name	C-X-C chemokine receptor type 2
UniProt accession	P25025
Gene	CXCR2
Organism	Homo sapiens
Length	360 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (2)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (951)

Diseases linked to this target (Open Targets).

neutrophil count · score 0.58
leukocyte count · score 0.58
neutrophil percentage of leukocytes · score 0.57
lymphocyte percentage of leukocytes · score 0.56
monocyte percentage of leukocytes · score 0.54
type 1 diabetes mellitus · score 0.35
ulcerative colitis · score 0.29
glioblastoma multiforme · score 0.28
pneumonia · score 0.28
COVID-19 · score 0.27

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P25025-F1	alphafold	PREDICTED	79.58	—

Amino-acid sequence (360 residues)

MEDFNMESDS FEDFWKGEDL SNYSYSSTLP PFLLDAAPCE PESLEINKYF VVIIYALVFL LSLLGNSLVM LVILYSRVGR SVTDVYLLNL ALADLLFALT LPIWAASKVN GWIFGTFLCK VVSLLKEVNF YSGILLLACI SVDRYLAIVH ATRTLTQKRY LVKFICLSIW GLSLLLALPV LLFRRTVYSS NVSPACYEDM GNNTANWRML LRILPQSFGF IVPLLIMLFC YGFTLRTLFK AHMGQKHRAM RVIFAVVLIF LLCWLPYNLV LLADTLMRTQ VIQETCERRN HIDRALDATE ILGILHSCLN PLIYAFIGQK FRHGLLKILA IHGLISKDSL PKDSRPSFVG SSSGHTSTTL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards