About Collagen alpha-2(VIII) chain
Collagen alpha-2(VIII) chain (COL8A2) is a protein
from Homo sapiens identified by UniProt accession
P25067, 703 residues long.
MolForge cross-references it against 0 known binders and
134 disease associations.
Target properties
| Protein name | Collagen alpha-2(VIII) chain |
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| UniProt accession | P25067 |
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| Gene | COL8A2 |
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| Organism | Homo sapiens |
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| Length | 703 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (134)
Diseases linked to this target (Open Targets).
- Fuchs endothelial corneal dystrophy · score 0.75
- Abnormality of the skeletal system · score 0.58
- posterior polymorphous corneal dystrophy · score 0.52
- body fat percentage · score 0.46
- appendicular lean mass · score 0.42
- intraocular pressure measurement · score 0.32
- central corneal thickness · score 0.32
- body height · score 0.30
- sitting height measurement · score 0.28
- neurodegenerative disease · score 0.28
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P25067-F1 | alphafold | PREDICTED | 56.33 | — |
Amino-acid sequence (703 residues)
MLGTLTPLSS LLLLLLVLVL GCGPRASSGG GAGGAAGYAP VKYIQPMQKG PVGPPFREGK GQYLEMPLPL LPMDLKGEPG PPGKPGPRGP PGPPGFPGKP GMGKPGLHGQ PGPAGPPGFS RMGKAGPPGL PGKVGPPGQP GLRGEPGIRG DQGLRGPPGP PGLPGPSGIT IPGKPGAQGV PGPPGFQGEP GPQGEPGPPG DRGLKGDNGV GQPGLPGAPG QGGAPGPPGL PGPAGLGKPG LDGLPGAPGD KGESGPPGVP GPRGEPGAVG PKGPPGVDGV GVPGAAGLPG PQGPSGAKGE PGTRGPPGLI GPTGYGMPGL PGPKGDRGPA GVPGLLGDRG EPGEDGEPGE QGPQGLGGPP GLPGSAGLPG RRGPPGPKGE AGPGGPPGVP GIRGDQGPSG LAGKPGVPGE RGLPGAHGPP GPTGPKGEPG FTGRPGGPGV AGALGQKGDL GLPGQPGLRG PSGIPGLQGP AGPIGPQGLP GLKGEPGLPG PPGEGRAGEP GTAGPTGPPG VPGSPGITGP PGPPGPPGPP GAPGAFDETG IAGLHLPNGG VEGAVLGKGG KPQFGLGELS AHATPAFTAV LTSPFPASGM PVKFDRTLYN GHSGYNPATG IFTCPVGGVY YFAYHVHVKG TNVWVALYKN NVPATYTYDE YKKGYLDQAS GGAVLQLRPN DQVWVQMPSD QANGLYSTEY IHSSFSGFLL CPT
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