N-formyl peptide receptor 3 (FPR3)

About N-formyl peptide receptor 3

N-formyl peptide receptor 3 (FPR3) is a protein from Homo sapiens identified by UniProt accession P25089, 353 residues long. MolForge cross-references it against 0 known binders and 88 disease associations.

Target properties

Protein name	N-formyl peptide receptor 3
UniProt accession	P25089
Gene	FPR3
Organism	Homo sapiens
Length	353 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (88)

Diseases linked to this target (Open Targets).

eosinophil count · score 0.35
high density lipoprotein cholesterol measurement · score 0.35
glioblastoma multiforme · score 0.26
blood protein measurement · score 0.26
alcohol drinking · score 0.26
ovarian cancer · score 0.25
neutrophil percentage of granulocytes · score 0.25
eosinophil percentage of leukocytes · score 0.24
neutrophil percentage of leukocytes · score 0.23
electrocardiography · score 0.21

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P25089-F1	alphafold	PREDICTED	83.40	—

Amino-acid sequence (353 residues)

METNFSIPLN ETEEVLPEPA GHTVLWIFSL LVHGVTFVFG VLGNGLVIWV AGFRMTRTVN TICYLNLALA DFSFSAILPF RMVSVAMREK WPFGSFLCKL VHVMIDINLF VSVYLITIIA LDRCICVLHP AWAQNHRTMS LAKRVMTGLW IFTIVLTLPN FIFWTTISTT NGDTYCIFNF AFWGDTAVER LNVFITMAKV FLILHFIIGF SVPMSIITVC YGIIAAKIHR NHMIKSSRPL RVFAAVVASF FICWFPYELI GILMAVWLKE MLLNGKYKII LVLINPTSSL AFFNSCLNPI LYVFMGRNFQ ERLIRSLPTS LERALTEVPD SAQTSNTDTT SASPPEETEL QAM

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards