N-formyl peptide receptor 2 (FPR2)

About N-formyl peptide receptor 2

N-formyl peptide receptor 2 (FPR2) is a protein from Homo sapiens identified by UniProt accession P25090, 351 residues long. MolForge cross-references it against 0 known binders and 426 disease associations.

Target properties

Protein name	N-formyl peptide receptor 2
UniProt accession	P25090
Gene	FPR2
Organism	Homo sapiens
Length	351 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (426)

Diseases linked to this target (Open Targets).

glioblastoma multiforme · score 0.29
neurodegenerative disease · score 0.27
breast adenocarcinoma · score 0.25
head and neck squamous cell carcinoma · score 0.16
cutaneous melanoma · score 0.13
lung adenocarcinoma · score 0.12
prostate adenocarcinoma · score 0.10
Sepsis · score 0.08
non-alcoholic fatty liver disease · score 0.08
cystic fibrosis · score 0.08

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P25090-F1	alphafold	PREDICTED	84.82	—

Amino-acid sequence (351 residues)

METNFSTPLN EYEEVSYESA GYTVLRILPL VVLGVTFVLG VLGNGLVIWV AGFRMTRTVT TICYLNLALA DFSFTATLPF LIVSMAMGEK WPFGWFLCKL IHIVVDINLF GSVFLIGFIA LDRCICVLHP VWAQNHRTVS LAMKVIVGPW ILALVLTLPV FLFLTTVTIP NGDTYCTFNF ASWGGTPEER LKVAITMLTA RGIIRFVIGF SLPMSIVAIC YGLIAAKIHK KGMIKSSRPL RVLTAVVASF FICWFPFQLV ALLGTVWLKE MLFYGKYKII DILVNPTSSL AFFNSCLNPM LYVFVGQDFR ERLIHSLPTS LERALSEDSA PTNDTAANSA SPPAETELQA M

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards