Atypical chemokine receptor 3 (ACKR3)

About Atypical chemokine receptor 3

Atypical chemokine receptor 3 (ACKR3) is a protein from Homo sapiens identified by UniProt accession P25106, 362 residues long. MolForge cross-references it against 0 known binders and 618 disease associations.

Target properties

Protein name	Atypical chemokine receptor 3
UniProt accession	P25106
Gene	ACKR3
Organism	Homo sapiens
Length	362 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (1)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (618)

Diseases linked to this target (Open Targets).

oculomotor-abducens synkinesis · score 0.45
neuroimaging measurement · score 0.44
cortical surface area measurement · score 0.43
cutaneous melanoma · score 0.37
pancreatic neoplasm · score 0.37
colon adenocarcinoma · score 0.37
colorectal adenocarcinoma · score 0.37
Endometrial Endometrioid Adenocarcinoma · score 0.37
hepatocellular carcinoma · score 0.30
cortical thickness · score 0.30

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P25106-F1	alphafold	PREDICTED	82.46	—

Amino-acid sequence (362 residues)

MDLHLFDYSE PGNFSDISWP CNSSDCIVVD TVMCPNMPNK SVLLYTLSFI YIFIFVIGMI ANSVVVWVNI QAKTTGYDTH CYILNLAIAD LWVVLTIPVW VVSLVQHNQW PMGELTCKVT HLIFSINLFG SIFFLTCMSV DRYLSITYFT NTPSSRKKMV RRVVCILVWL LAFCVSLPDT YYLKTVTSAS NNETYCRSFY PEHSIKEWLI GMELVSVVLG FAVPFSIIAV FYFLLARAIS ASSDQEKHSS RKIIFSYVVV FLVCWLPYHV AVLLDIFSIL HYIPFTCRLE HALFTALHVT QCLSLVHCCV NPVLYSFINR NYRYELMKAF IFKYSAKTGL TKLIDASRVS ETEYSALEQS TK

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards