Proteinase-activated receptor 1 (F2R)

About Proteinase-activated receptor 1

Proteinase-activated receptor 1 (F2R) is a protein from Homo sapiens identified by UniProt accession P25116, 425 residues long. MolForge cross-references it against 0 known binders and 376 disease associations.

Target properties

Protein name	Proteinase-activated receptor 1
UniProt accession	P25116
Gene	F2R
Organism	Homo sapiens
Length	425 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (1)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (376)

Diseases linked to this target (Open Targets).

myocardial infarction · score 0.57
peripheral arterial disease · score 0.55
neurodegenerative disease · score 0.49
stroke · score 0.46
serum albumin measurement · score 0.42
coronary artery disease · score 0.41
reticulocyte count · score 0.38
Recurrent thrombophlebitis · score 0.37
mean corpuscular hemoglobin · score 0.36
mean platelet volume · score 0.36

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P25116-F1	alphafold	PREDICTED	74.59	—

Amino-acid sequence (425 residues)

MGPRRLLLVA ACFSLCGPLL SARTRARRPE SKATNATLDP RSFLLRNPND KYEPFWEDEE KNESGLTEYR LVSINKSSPL QKQLPAFISE DASGYLTSSW LTLFVPSVYT GVFVVSLPLN IMAIVVFILK MKVKKPAVVY MLHLATADVL FVSVLPFKIS YYFSGSDWQF GSELCRFVTA AFYCNMYASI LLMTVISIDR FLAVVYPMQS LSWRTLGRAS FTCLAIWALA IAGVVPLLLK EQTIQVPGLN ITTCHDVLNE TLLEGYYAYY FSAFSAVFFF VPLIISTVCY VSIIRCLSSS AVANRSKKSR ALFLSAAVFC IFIICFGPTN VLLIAHYSFL SHTSTTEAAY FAYLLCVCVS SISCCIDPLI YYYASSECQR YVYSILCCKE SSDPSSYNSS GQLMASKMDT CSSNLNNSIY KKLLT

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards