Myelin protein P0 (MPZ)

About Myelin protein P0

Myelin protein P0 (MPZ) is a protein from Homo sapiens identified by UniProt accession P25189, 248 residues long. MolForge cross-references it against 0 known binders and 449 disease associations.

Target properties

Protein name	Myelin protein P0
UniProt accession	P25189
Gene	MPZ
Organism	Homo sapiens
Length	248 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (449)

Diseases linked to this target (Open Targets).

Charcot-Marie-Tooth disease type 1B · score 0.84
Dejerine-Sottas syndrome · score 0.83
Charcot-Marie-Tooth disease type 2I · score 0.80
Charcot-Marie-Tooth disease type 3 · score 0.78
Autosomal dominant intermediate Charcot-Marie-Tooth disease type D · score 0.77
Autosomal dominant Charcot-Marie-Tooth disease type 2I · score 0.77
Charcot-Marie-Tooth disease dominant intermediate D · score 0.75
Charcot-Marie-Tooth disease type 2J · score 0.74
neuropathy · score 0.72
Autosomal dominant Charcot-Marie-Tooth disease type 2J · score 0.71

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P25189-F1	alphafold	PREDICTED	81.71	—

Amino-acid sequence (248 residues)

MAPGAPSSSP SPILAVLLFS SLVLSPAQAI VVYTDREVHG AVGSRVTLHC SFWSSEWVSD DISFTWRYQP EGGRDAISIF HYAKGQPYID EVGTFKERIQ WVGDPRWKDG SIVIHNLDYS DNGTFTCDVK NPPDIVGKTS QVTLYVFEKV PTRYGVVLGA VIGGVLGVVL LLLLLFYVVR YCWLRRQAAL QRRLSAMEKG KLHKPGKDAS KRGRQTPVLY AMLDHSRSTK AVSEKKAKGL GESRKDKK

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards