Nuclear transcription factor Y subunit beta (NFYB)

About Nuclear transcription factor Y subunit beta

Nuclear transcription factor Y subunit beta (NFYB) is a protein from Homo sapiens identified by UniProt accession P25208, 207 residues long. MolForge cross-references it against 0 known binders and 62 disease associations.

Target properties

Protein name	Nuclear transcription factor Y subunit beta
UniProt accession	P25208
Gene	NFYB
Organism	Homo sapiens
Length	207 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (62)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.54
PR interval · score 0.26
gastric cancer · score 0.07
gonorrhea · score 0.07
glioblastoma multiforme · score 0.06
cancer · score 0.04
neoplasm · score 0.03
sarcoma · score 0.03
Ehlers-Danlos syndrome, musculocontractural type · score 0.02
malaria · score 0.02

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P25208-F1	alphafold	PREDICTED	69.59	—

Amino-acid sequence (207 residues)

MTMDGDSSTT DASQLGISAD YIGGSHYVIQ PHDDTEDSMN DHEDTNGSKE SFREQDIYLP IANVARIMKN AIPQTGKIAK DAKECVQECV SEFISFITSE ASERCHQEKR KTINGEDILF AMSTLGFDSY VEPLKLYLQK FREAMKGEKG IGGAVTATDG LSEELTEEAF TNQLPAGLIT TDGQQQNVMV YTTSYQQISG VQQIQFS

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards