Small ribosomal subunit protein eS12 (RPS12)

About Small ribosomal subunit protein eS12

Small ribosomal subunit protein eS12 (RPS12) is a protein from Homo sapiens identified by UniProt accession P25398, 132 residues long. MolForge cross-references it against 0 known binders and 56 disease associations.

Target properties

Protein name	Small ribosomal subunit protein eS12
UniProt accession	P25398
Gene	RPS12
Organism	Homo sapiens
Length	132 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (56)

Diseases linked to this target (Open Targets).

Duchenne muscular dystrophy · score 0.50
cystic fibrosis · score 0.50
influenza · score 0.46
neurodegenerative disease · score 0.45
severe acute respiratory syndrome · score 0.37
COVID-19 · score 0.37
lysosomal storage disease · score 0.29
Becker muscular dystrophy · score 0.29
qualitative or quantitative defects of dystrophin · score 0.26
heel bone mineral density · score 0.24

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P25398-F1	alphafold	PREDICTED	80.39	—

Amino-acid sequence (132 residues)

MAEEGIAAGG VMDVNTALQE VLKTALIHDG LARGIREAAK ALDKRQAHLC VLASNCDEPM YVKLVEALCA EHQINLIKVD DNKKLGEWVG LCKIDREGKP RKVVGCSCVV VKDYGKESQA KDVIEEYFKC KK

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards