About Bromodomain-containing protein 2
Bromodomain-containing protein 2 (BRD2) is a protein
from Homo sapiens identified by UniProt accession
P25440, 801 residues long.
MolForge cross-references it against 0 known binders and
1,053 disease associations.
Target properties
| Protein name | Bromodomain-containing protein 2 |
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| UniProt accession | P25440 |
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| Gene | BRD2 |
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| Organism | Homo sapiens |
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| Length | 801 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (1053)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.54
- Parkinson disease · score 0.37
- Alzheimer disease · score 0.37
- multiple sclerosis · score 0.37
- lysosomal storage disease · score 0.37
- neuroinflammatory disorder · score 0.31
- coronary artery disease · score 0.29
- schizophrenia · score 0.15
- neoplasm · score 0.14
- inflammatory bowel disease · score 0.14
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P25440-F1 | alphafold | PREDICTED | 64.08 | — |
Amino-acid sequence (801 residues)
MLQNVTPHNK LPGEGNAGLL GLGPEAAAPG KRIRKPSLLY EGFESPTMAS VPALQLTPAN PPPPEVSNPK KPGRVTNQLQ YLHKVVMKAL WKHQFAWPFR QPVDAVKLGL PDYHKIIKQP MDMGTIKRRL ENNYYWAASE CMQDFNTMFT NCYIYNKPTD DIVLMAQTLE KIFLQKVASM PQEEQELVVT IPKNSHKKGA KLAALQGSVT SAHQVPAVSS VSHTALYTPP PEIPTTVLNI PHPSVISSPL LKSLHSAGPP LLAVTAAPPA QPLAKKKGVK RKADTTTPTP TAILAPGSPA SPPGSLEPKA ARLPPMRRES GRPIKPPRKD LPDSQQQHQS SKKGKLSEQL KHCNGILKEL LSKKHAAYAW PFYKPVDASA LGLHDYHDII KHPMDLSTVK RKMENRDYRD AQEFAADVRL MFSNCYKYNP PDHDVVAMAR KLQDVFEFRY AKMPDEPLEP GPLPVSTAMP PGLAKSSSES SSEESSSESS SEEEEEEDEE DEEEEESESS DSEEERAHRL AELQEQLRAV HEQLAALSQG PISKPKRKRE KKEKKKKRKA EKHRGRAGAD EDDKGPRAPR PPQPKKSKKA SGSGGGSAAL GPSGFGPSGG SGTKLPKKAT KTAPPALPTG YDSEEEEESR PMSYDEKRQL SLDINKLPGE KLGRVVHIIQ AREPSLRDSN PEEIEIDFET LKPSTLRELE RYVLSCLRKK PRKPYTIKKP VGKTKEELAL EKKRELEKRL QDVSGQLNST KKPPKKANEK TESSSAQQVA VSRLSASSSS SDSSSSSSSS SSSDTSDSDS G
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