Transcriptional repressor protein YY1 (YY1)

About Transcriptional repressor protein YY1

Transcriptional repressor protein YY1 (YY1) is a protein from Homo sapiens identified by UniProt accession P25490, 414 residues long. MolForge cross-references it against 0 known binders and 373 disease associations.

Target properties

Protein name	Transcriptional repressor protein YY1
UniProt accession	P25490
Gene	YY1
Organism	Homo sapiens
Length	414 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (373)

Diseases linked to this target (Open Targets).

Gabriele de Vries syndrome · score 0.76
Intellectual disability · score 0.59
genetic disorder · score 0.45
Neurodevelopmental disorder · score 0.30
glioblastoma multiforme · score 0.28
neurodegenerative disease · score 0.27
disease progression measurement · score 0.24
metastasis measurement · score 0.24
endometrial cancer · score 0.23
low grade glioma · score 0.23

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P25490-F1	alphafold	PREDICTED	50.59	—

Amino-acid sequence (414 residues)

MASGDTLYIA TDGSEMPAEI VELHEIEVET IPVETIETTV VGEEEEEDDD DEDGGGGDHG GGGGHGHAGH HHHHHHHHHH PPMIALQPLV TDDPTQVHHH QEVILVQTRE EVVGGDDSDG LRAEDGFEDQ ILIPVPAPAG GDDDYIEQTL VTVAAAGKSG GGGSSSSGGG RVKKGGGKKS GKKSYLSGGA GAAGGGGADP GNKKWEQKQV QIKTLEGEFS VTMWSSDEKK DIDHETVVEE QIIGENSPPD YSEYMTGKKL PPGGIPGIDL SDPKQLAEFA RMKPRKIKED DAPRTIACPH KGCTKMFRDN SAMRKHLHTH GPRVHVCAEC GKAFVESSKL KRHQLVHTGE KPFQCTFEGC GKRFSLDFNL RTHVRIHTGD RPYVCPFDGC NKKFAQSTNL KSHILTHAKA KNNQ

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards