DnaJ homolog subfamily B member 2 (DNAJB2)

About DnaJ homolog subfamily B member 2

DnaJ homolog subfamily B member 2 (DNAJB2) is a protein from Homo sapiens identified by UniProt accession P25686, 324 residues long. MolForge cross-references it against 0 known binders and 68 disease associations.

Target properties

Protein name	DnaJ homolog subfamily B member 2
UniProt accession	P25686
Gene	DNAJB2
Organism	Homo sapiens
Length	324 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (68)

Diseases linked to this target (Open Targets).

neuronopathy, distal hereditary motor, autosomal recessive 5 · score 0.73
Spinal muscular atrophy with respiratory distress type 1 · score 0.65
Charcot-Marie-Tooth disease axonal type 2T · score 0.50
genetic disorder · score 0.47
charcot-marie-tooth disease, axonal, type 2t · score 0.37
X-linked Charcot-Marie-Tooth disease type 1 · score 0.34
Charcot-Marie-Tooth disease X-linked dominant 1 · score 0.34
neurodegenerative disease · score 0.33
body mass index · score 0.25
Charcot-Marie-Tooth disease · score 0.18

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P25686-F1	alphafold	PREDICTED	67.35	—

Amino-acid sequence (324 residues)

MASYYEILDV PRSASADDIK KAYRRKALQW HPDKNPDNKE FAEKKFKEVA EAYEVLSDKH KREIYDRYGR EGLTGTGTGP SRAEAGSGGP GFTFTFRSPE EVFREFFGSG DPFAELFDDL GPFSELQNRG SRHSGPFFTF SSSFPGHSDF SSSSFSFSPG AGAFRSVSTS TTFVQGRRIT TRRIMENGQE RVEVEEDGQL KSVTINGVPD DLALGLELSR REQQPSVTSR SGGTQVQQTP ASCPLDSDLS EDEDLQLAMA YSLSEMEAAG KKPAGGREAQ HRRQGRPKAQ HQDPGLGGTQ EGARGEATKR SPSPEEKASR CLIL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards