About ATP synthase F(1) complex subunit alpha, mitochondrial
ATP synthase F(1) complex subunit alpha, mitochondrial (ATP5F1A) is a protein
from Homo sapiens identified by UniProt accession
P25705, 553 residues long.
MolForge cross-references it against 0 known binders and
124 disease associations.
Target properties
| Protein name | ATP synthase F(1) complex subunit alpha, mitochondrial |
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| UniProt accession | P25705 |
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| Gene | ATP5F1A |
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| Organism | Homo sapiens |
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| Length | 553 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (124)
Diseases linked to this target (Open Targets).
- combined oxidative phosphorylation deficiency 22 · score 0.61
- mitochondrial complex V (ATP synthase) deficiency, nuclear type 4A · score 0.56
- Isolated ATP synthase deficiency · score 0.46
- mitochondrial complex V (ATP synthase) deficiency nuclear type 4B · score 0.45
- Mitochondrial encephalopathy · score 0.37
- Red cell distribution width · score 0.27
- lactic acidosis · score 0.27
- genetic disorder · score 0.19
- mean corpuscular hemoglobin · score 0.18
- eosinophil count · score 0.13
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P25705-F1 | alphafold | PREDICTED | 88.21 | — |
Amino-acid sequence (553 residues)
MLSVRVAAAV VRALPRRAGL VSRNALGSSF IAARNFHASN THLQKTGTAE MSSILEERIL GADTSVDLEE TGRVLSIGDG IARVHGLRNV QAEEMVEFSS GLKGMSLNLE PDNVGVVVFG NDKLIKEGDI VKRTGAIVDV PVGEELLGRV VDALGNAIDG KGPIGSKTRR RVGLKAPGII PRISVREPMQ TGIKAVDSLV PIGRGQRELI IGDRQTGKTS IAIDTIINQK RFNDGSDEKK KLYCIYVAIG QKRSTVAQLV KRLTDADAMK YTIVVSATAS DAAPLQYLAP YSGCSMGEYF RDNGKHALII YDDLSKQAVA YRQMSLLLRR PPGREAYPGD VFYLHSRLLE RAAKMNDAFG GGSLTALPVI ETQAGDVSAY IPTNVISITD GQIFLETELF YKGIRPAINV GLSVSRVGSA AQTRAMKQVA GTMKLELAQY REVAAFAQFG SDLDAATQQL LSRGVRLTEL LKQGQYSPMA IEEQVAVIYA GVRGYLDKLE PSKITKFENA FLSHVVSQHQ ALLGTIRADG KISEQSDAKL KEIVTNFLAG FEA
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