Proteasome subunit alpha type-1 (PSMA1)

About Proteasome subunit alpha type-1

Proteasome subunit alpha type-1 (PSMA1) is a protein from Homo sapiens identified by UniProt accession P25786, 263 residues long. MolForge cross-references it against 0 known binders and 116 disease associations.

Target properties

Protein name	Proteasome subunit alpha type-1
UniProt accession	P25786
Gene	PSMA1
Organism	Homo sapiens
Length	263 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (2)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (116)

Diseases linked to this target (Open Targets).

HIV infection · score 0.46
body height · score 0.31
diastolic blood pressure · score 0.30
breast adenocarcinoma · score 0.30
urate measurement · score 0.30
bone density · score 0.30
high density lipoprotein cholesterol measurement · score 0.28
glioblastoma multiforme · score 0.28
head and neck squamous cell carcinoma · score 0.28
gastric adenocarcinoma · score 0.27

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P25786-F1	alphafold	PREDICTED	91.84	—

Amino-acid sequence (263 residues)

MFRNQYDNDV TVWSPQGRIH QIEYAMEAVK QGSATVGLKS KTHAVLVALK RAQSELAAHQ KKILHVDNHI GISIAGLTAD ARLLCNFMRQ ECLDSRFVFD RPLPVSRLVS LIGSKTQIPT QRYGRRPYGV GLLIAGYDDM GPHIFQTCPS ANYFDCRAMS IGARSQSART YLERHMSEFM ECNLNELVKH GLRALRETLP AEQDLTTKNV SIGIVGKDLE FTIYDDDDVS PFLEGLEERP QRKAQPAQPA DEPAEKADEP MEH

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards