About Proteasome subunit alpha type-2
Proteasome subunit alpha type-2 (PSMA2) is a protein
from Homo sapiens identified by UniProt accession
P25787, 234 residues long.
MolForge cross-references it against 0 known binders and
61 disease associations.
Target properties
| Protein name | Proteasome subunit alpha type-2 |
|---|
| UniProt accession | P25787 |
|---|
| Gene | PSMA2 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 234 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (61)
Diseases linked to this target (Open Targets).
- HIV infection · score 0.46
- neurodegenerative disease · score 0.44
- cortical surface area measurement · score 0.31
- endometrial cancer · score 0.29
- neuroimaging measurement · score 0.28
- glioblastoma multiforme · score 0.28
- head and neck squamous cell carcinoma · score 0.28
- brain measurement · score 0.27
- cortical thickness · score 0.25
- neurofibrillary tangles measurement · score 0.23
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P25787-F1 | alphafold | PREDICTED | 94.74 | — |
Amino-acid sequence (234 residues)
MAERGYSFSL TTFSPSGKLV QIEYALAAVA GGAPSVGIKA ANGVVLATEK KQKSILYDER SVHKVEPITK HIGLVYSGMG PDYRVLVHRA RKLAQQYYLV YQEPIPTAQL VQRVASVMQE YTQSGGVRPF GVSLLICGWN EGRPYLFQSD PSGAYFAWKA TAMGKNYVNG KTFLEKRYNE DLELEDAIHT AILTLKESFE GQMTEDNIEV GICNEAGFRR LTPTEVKDYL AAIA
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