About Proteasome subunit alpha type-3
Proteasome subunit alpha type-3 (PSMA3) is a protein
from Homo sapiens identified by UniProt accession
P25788, 255 residues long.
MolForge cross-references it against 0 known binders and
126 disease associations.
Target properties
| Protein name | Proteasome subunit alpha type-3 |
|---|
| UniProt accession | P25788 |
|---|
| Gene | PSMA3 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 255 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (126)
Diseases linked to this target (Open Targets).
- HIV infection · score 0.46
- glioblastoma multiforme · score 0.37
- neurodegenerative disease · score 0.36
- breast adenocarcinoma · score 0.30
- endometrial cancer · score 0.29
- lung adenocarcinoma · score 0.29
- clear cell renal carcinoma · score 0.27
- gastric adenocarcinoma · score 0.27
- multiple myeloma · score 0.25
- Red cell distribution width · score 0.14
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P25788-F1 | alphafold | PREDICTED | 94.49 | — |
Amino-acid sequence (255 residues)
MSSIGTGYDL SASTFSPDGR VFQVEYAMKA VENSSTAIGI RCKDGVVFGV EKLVLSKLYE EGSNKRLFNV DRHVGMAVAG LLADARSLAD IAREEASNFR SNFGYNIPLK HLADRVAMYV HAYTLYSAVR PFGCSFMLGS YSVNDGAQLY MIDPSGVSYG YWGCAIGKAR QAAKTEIEKL QMKEMTCRDI VKEVAKIIYI VHDEVKDKAF ELELSWVGEL TNGRHEIVPK DIREEAEKYA KESLKEEDES DDDNM
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