About Proteasome subunit alpha type-4
Proteasome subunit alpha type-4 (PSMA4) is a protein
from Homo sapiens identified by UniProt accession
P25789, 261 residues long.
MolForge cross-references it against 0 known binders and
122 disease associations.
Target properties
| Protein name | Proteasome subunit alpha type-4 |
|---|
| UniProt accession | P25789 |
|---|
| Gene | PSMA4 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 261 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (122)
Diseases linked to this target (Open Targets).
- HIV infection · score 0.46
- lung adenocarcinoma · score 0.29
- ovarian cancer · score 0.29
- squamous cell lung carcinoma · score 0.28
- glioblastoma multiforme · score 0.28
- head and neck squamous cell carcinoma · score 0.28
- clear cell renal carcinoma · score 0.27
- neurodegenerative disease · score 0.18
- cigarettes per day measurement · score 0.16
- serum metabolite measurement · score 0.12
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P25789-F1 | alphafold | PREDICTED | 93.47 | — |
Amino-acid sequence (261 residues)
MSRRYDSRTT IFSPEGRLYQ VEYAMEAIGH AGTCLGILAN DGVLLAAERR NIHKLLDEVF FSEKIYKLNE DMACSVAGIT SDANVLTNEL RLIAQRYLLQ YQEPIPCEQL VTALCDIKQA YTQFGGKRPF GVSLLYIGWD KHYGFQLYQS DPSGNYGGWK ATCIGNNSAA AVSMLKQDYK EGEMTLKSAL ALAIKVLNKT MDVSKLSAEK VEIATLTREN GKTVIRVLKQ KEVEQLIKKH EEEEAKAERE KKEKEQKEKD K
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