Mitochondrial brown fat uncoupling protein 1 (UCP1)

About Mitochondrial brown fat uncoupling protein 1

Mitochondrial brown fat uncoupling protein 1 (UCP1) is a protein from Homo sapiens identified by UniProt accession P25874, 307 residues long. MolForge cross-references it against 0 known binders and 346 disease associations.

Target properties

Protein name	Mitochondrial brown fat uncoupling protein 1
UniProt accession	P25874
Gene	UCP1
Organism	Homo sapiens
Length	307 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (346)

Diseases linked to this target (Open Targets).

PHF-tau measurement · score 0.21
Obesity · score 0.10
type 2 diabetes mellitus · score 0.10
acute kidney failure · score 0.08
breast cancer · score 0.08
renal cell carcinoma · score 0.08
hepatocellular carcinoma · score 0.08
triple-negative breast cancer · score 0.07
Rheumatoid arthritis · score 0.07
nonpapillary renal cell carcinoma · score 0.07

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P25874-F1	alphafold	PREDICTED	76.14	—

Amino-acid sequence (307 residues)

MGGLTASDVH PTLGVQLFSA GIAACLADVI TFPLDTAKVR LQVQGECPTS SVIRYKGVLG TITAVVKTEG RMKLYSGLPA GLQRQISSAS LRIGLYDTVQ EFLTAGKETA PSLGSKILAG LTTGGVAVFI GQPTEVVKVR LQAQSHLHGI KPRYTGTYNA YRIIATTEGL TGLWKGTTPN LMRSVIINCT ELVTYDLMKE AFVKNNILAD DVPCHLVSAL IAGFCATAMS SPVDVVKTRF INSPPGQYKS VPNCAMKVFT NEGPTAFFKG LVPSFLRLGS WNVIMFVCFE QLKRELSKSR QTMDCAT

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards