Neuropeptide Y receptor type 1 (NPY1R)

About Neuropeptide Y receptor type 1

Neuropeptide Y receptor type 1 (NPY1R) is a protein from Homo sapiens identified by UniProt accession P25929, 384 residues long. MolForge cross-references it against 0 known binders and 341 disease associations.

Target properties

Protein name	Neuropeptide Y receptor type 1
UniProt accession	P25929
Gene	NPY1R
Organism	Homo sapiens
Length	384 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (341)

Diseases linked to this target (Open Targets).

mathematical ability · score 0.45
self reported educational attainment · score 0.40
wellbeing measurement · score 0.37
triglyceride measurement · score 0.29
breast adenocarcinoma · score 0.17
daytime rest measurement · score 0.17
head and neck squamous cell carcinoma · score 0.16
low grade glioma · score 0.14
neuroblastoma · score 0.12
prostate adenocarcinoma · score 0.10

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P25929-F1	alphafold	PREDICTED	79.87	—

Amino-acid sequence (384 residues)

MNSTLFSQVE NHSVHSNFSE KNAQLLAFEN DDCHLPLAMI FTLALAYGAV IILGVSGNLA LIIIILKQKE MRNVTNILIV NLSFSDLLVA IMCLPFTFVY TLMDHWVFGE AMCKLNPFVQ CVSITVSIFS LVLIAVERHQ LIINPRGWRP NNRHAYVGIA VIWVLAVASS LPFLIYQVMT DEPFQNVTLD AYKDKYVCFD QFPSDSHRLS YTTLLLVLQY FGPLCFIFIC YFKIYIRLKR RNNMMDKMRD NKYRSSETKR INIMLLSIVV AFAVCWLPLT IFNTVFDWNH QIIATCNHNL LFLLCHLTAM ISTCVNPIFY GFLNKNFQRD LQFFFNFCDF RSRDDDYETI AMSTMHTDVS KTSLKQASPV AFKKINNNDD NEKI

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards