NF-kappa-B inhibitor alpha (NFKBIA)

About NF-kappa-B inhibitor alpha

NF-kappa-B inhibitor alpha (NFKBIA) is a protein from Homo sapiens identified by UniProt accession P25963, 317 residues long. MolForge cross-references it against 0 known binders and 866 disease associations.

Target properties

Protein name	NF-kappa-B inhibitor alpha
UniProt accession	P25963
Gene	NFKBIA
Organism	Homo sapiens
Length	317 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (866)

Diseases linked to this target (Open Targets).

Hypohidrotic ectodermal dysplasia with immunodeficiency · score 0.75
ectodermal dysplasia and immunodeficiency 2 · score 0.75
hypohidrotic ectodermal dysplasia · score 0.53
systolic blood pressure · score 0.47
lymphocyte count · score 0.47
leukocyte count · score 0.45
diffuse large B-cell lymphoma · score 0.44
pulse pressure measurement · score 0.43
eosinophil count · score 0.42
psoriasis · score 0.39

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P25963-F1	alphafold	PREDICTED	83.49	—

Amino-acid sequence (317 residues)

MFQAAERPQE WAMEGPRDGL KKERLLDDRH DSGLDSMKDE EYEQMVKELQ EIRLEPQEVP RGSEPWKQQL TEDGDSFLHL AIIHEEKALT MEVIRQVKGD LAFLNFQNNL QQTPLHLAVI TNQPEIAEAL LGAGCDPELR DFRGNTPLHL ACEQGCLASV GVLTQSCTTP HLHSILKATN YNGHTCLHLA SIHGYLGIVE LLVSLGADVN AQEPCNGRTA LHLAVDLQNP DLVSLLLKCG ADVNRVTYQG YSPYQLTWGR PSTRIQQQLG QLTLENLQML PESEDEESYD TESEFTEFTE DELPYDDCVF GGQRLTL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards